Cellular senescence in osteoarthritis pathology
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چکیده
منابع مشابه
Cellular senescence in osteoarthritis pathology
Cellular senescence is a state of stable proliferation arrest of cells. The senescence pathway has many beneficial effects and is seen to be activated in damaged/stressed cells, as well as during embryonic development and wound healing. However, the persistence and accumulation of senescent cells in various tissues can also impair function and have been implicated in the pathogenesis of many ag...
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- It is well accepted that age is an important contributing factor to poor cartilage repair following injury, and to the development of osteoarthritis. Cellular senescence, the loss of the ability of cells to divide, has been noted as the major factor contributing to age-related changes in cartilage homeostasis, function, and response to injury. The underlying mechanisms of cellular senescence,...
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Background: Aging is one of the important factors in the development of age-related diseases. Acrylamide can be produced during carbohydrate-rich foods prepared at high temperatures. Recently, studies showed that acrylamide can induce cellular senescence. On the other hand, Rutin as a natural flavonoid, has a potent antioxidant activity. Objective: This study aims to evaluate the ptotective ef...
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developmental stage, and nutritional environment. Kobayashi et al. identified Holliday junction resolvase as a key factor in the dynamism of chloroplast nucleoids in the unicellular green algae Chlamydomonas reinhardtii. The gene encoding the resolvase is ubiquitously conserved among green plants. Disruption or down-regulation of this gene also disturbed chloroplast nucleoid organization and se...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2017
ISSN: 1474-9718
DOI: 10.1111/acel.12562